Chair of Computational Biology at Saarland University
Our research group studies two main biomedical phenomena:
- cell differentiation and reprogramming
- emergence of antibiotics/drug resistance in bacteria and cancer
For this, we employ molecular modelling and simulation methods as well as methods for data integration and data analysis.
In the area of cell differentiation, we analyze how multiple proteins aggregate into protein complexes or interact with DNA. Of particular interest is how these interactions are affected by post-translational or epigenetic modifications, or by alternative splicing.
In the area of emerging drug resistance, we map genome-wide mutation data onto regulatory and metabolic pathways. Also, we analyze by atomistic simulations and data mining how substrates interact with membrane transporters.
Our group collaborates closely with various experimental partners on campus and elsewhere and is embedded in the collaborative research center SFB 1027.