Special-topic Lecture Bioinformatics: Modern Methods in Drug Discovery WS 22/23


starting on October 31st; taking place in presence (if conditions allow) in building E2 1, room 001 and hybrid (via MS-Teams).


every second week as MS-Teams meeting, dates to be announced, please see table below


Registration for this course is available from September, 1st:
Log into the moodle system using the settings of your university account and use "self enrollment":

You will be added to the corresponding MS-Team subsequently by the lecturer.


Written exam, to be announced.

LSF registration is mandatory to participate in the exam; deadline is seven days before the exam date.

Note: This course will be presented in English, the final exam will be available in German too.


Re-exam: to be announced

LSF registration is mandatory to participate, deadline: seven days before the exam date.


This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"


  • basic knowledge of Organic Chemistry and Genetics
  • scope of the lectures:
    Bioinformatik I + II
    Computational Chemistry
    Softwarewerkzeuge der Bioinformatik or Structural Bioinformatics

The questionnaire gives you an idea about the required knowledge.

Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master Program Bioinformatics)
Computational Chemistry
Softwarewerkzeuge der Bioinformatik
Structural Bioinformatics (Master Program Bioinformatics)


The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

  • molecular origin of typical diseases and the mode of action of drugs
  • virtual substance libraries and query strategies
  • in silico eADMET models and filters, bioavailability
  • statistics and QSAR methods
  • metabolism, toxicology and adverse side effects, also considering biomarkers
  • polymorphism and susceptible genes
  • identification of orthologous genes to derive new targets and model organisms
  • current trends and strategies of drug design


Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam

Passing the two intermediate tests. These will be available in the moodle system.
First test: TBA
Second test: TBA


5 (2 V + 1 Ü)


This course is taught in English language.


Lectures/Tutorials Slides Exercises
Lecture 1, October 31 Lecture 1 Assignment 1
Lecture 2, November 7  Lecture 2 Assignment 2
Tutorial 1, November 10, tba Tutorial 1
Lecture 3, November 14  Lecture 3
Lecture 4, November 21  Lecture 4 Assignment 3
Tutorial 2, November 24 Tutorial 2
Lecture 5, November 28 Lecture 5
Lecture 6, December 5  Lecture 6 Assignment 4
Tutorial 3, December 8 Tutorial 3
1st Test, tba
Lecture 7, December 12 Lecture 7
Lecture 8, December 19 Lecture 8 Assignment 5
Tutorial 4, December 22 Tutorial 4
Lecture 9, January 2 Lecture 9
Lecture 10, January 9 Lecture 10
2nd Test, tba
Tutorial 5, January 12 Tutorial 5
Lecture 11, January 16 Lecture 11
Lecture 12, January 23 Lecture 12
Lecture 13, January 30 Lecture 13
February 6 (possibly final exam)