Written exam: to be announced

Note: This course will be presented in English, the final exam will be available in German too.

to be announced, presumably 1st week of the summer term

This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

• basic knowledge of Organic Chemistry and Genetics
• scope of the lectures:
  Bioinformatik I + II
  Computational Chemistry
  Softwarewerkzeuge der Bioinformatik or Structural Bioinformatics

The questionnaire gives you an idea about the required knowledge.
Due to technical limitations, the number of participants
will be limited to about 20.

Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master Program Bioinformatics)
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik
Structural Bioinformatics (Master Program Bioinformatics)

The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

• molecular origin of typical diseases and the mode of action of drugs
• virtual substance libraries and query strategies
• in silico eADMET models and filters, bioavailability
• statistics and QSAR methods
• metabolism, toxicology and adverse side effects, also considering biomarkers
• polymorphism and susceptible genes
• identification of orthologous genes to derive new targets and model organisms
• current trends and strategies of drug design

Grade of certification ("Schein") is based on the final exam only.

Passing the two intermediate tests. These will be available in the moodle system.
First test: to be announced
Second test: to be announced

5 (2 V + 1 Ü)

This course is taught in English language.