Lecturer
Tutor
Lecture
starting on October 25th; taking place in presence in building E2 1, room 001 (if possible) and online (videos will be available for download in the moodle system)
Tutorial
every second week as MS-Teams meeting, dates to be announced, please see table below
Registration
You have to register for this course in the moodle system. You will be added to the corresponding MS-Team for the tutorials.
Exam
Written exam: Monday, February 7th, 2:00 pm, lecture hall 002 in building E1 3; please find the results here.
LSF registration is mandatory to participate in the exam; deadline is January 31st, 2022.
Note: This course will be presented in English, the final exam will be available in German too.
Re-exam
Re-exam: Wednesday, April 13th, 2022, 2:00 pm - 4:00 pm, E2 1, seminar room 007.
LSF registration is mandatory to participate, deadline is April 6th, 2022.
Information
This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"
Requirements
- basic knowledge of Organic Chemistry and Genetics
- scope of the lectures:
Bioinformatik I + II
Computational Chemistry
Softwarewerkzeuge der Bioinformatik or Structural Bioinformatics
The questionnaire gives you an idea about the required knowledge.
Due to technical limitations, the number of participants
will be limited to about 20.
Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master Program Bioinformatics)
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik
Structural Bioinformatics (Master Program Bioinformatics)
Content
The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:
- molecular origin of typical diseases and the mode of action of drugs
- virtual substance libraries and query strategies
- in silico eADMET models and filters, bioavailability
- statistics and QSAR methods
- metabolism, toxicology and adverse side effects, also considering biomarkers
- polymorphism and susceptible genes
- identification of orthologous genes to derive new targets and model organisms
- current trends and strategies of drug design
Schein/Certification
Grade of certification ("Schein") is based on the final exam only.
Condition for participation in the final exam
Passing the two intermediate tests. These will be available in the moodle system.
First test: December 9th, 10:30 am
Second test: January 20th, 10:30 am
Leistungspunkte/Credits
5 (2 V + 1 Ü)
Language
This course is taught in English language.
Lectures
Lectures/Tutorials | Slides | Exercises |
Lecture 1, October 25 | Lecture 1 | Assignment 1 |
Lecture 2, November 8 | Lecture 2 | Assignment 2 |
Tutorial 1, November 11, 10:15 am online | Tutorial 1 | |
Lecture 3, November 15 | Lecture 3 | |
Lecture 4, November 22 | Lecture 4 | Assignment 3 |
Tutorial 2, November 25, 10:15 am online | Tutorial 2 | |
Lecture 5, November 29 | Lecture 5 | |
Lecture 6, December 6 | Lecture 6 | Assignment 4 |
Tutorial 3, December 9, 11:05 am online | Tutorial 3 Material: Floxacines.smi |
|
1st Test (in moodle), December 9, 10:30 am | ||
Lecture 7, December 13 | Lecture 7 | |
Lecture 8, January 3 | Lecture 8 | Assignment 5 |
Tutorial 4, January 6, 10:15 am online | Tutorial 4 | |
Lecture 9, January 10 | Lecture 9 | |
Lecture 10, January 17 | Lecture 10 | |
2nd Test (in moodle), January 20, 10:30 am | ||
Tutorial 5, January 20, 11:05 am online | ||
Lecture 11, January 24 | Lecture 11 | |
Lecture 12, January 31 | Lecture 12 | |
February 7 (exam) |