Special-topic Lecture Bioinformatics: Modern Methods in Drug Discovery WS 21/22

Lecture

starting on October 25th; taking place in presence in building E2 1, room 001 (if possible) and online (videos will be available for download in the moodle system)

Tutorial

every second week as MS-Teams meeting, dates to be announced, please see table below

Registration

You have to register for this course in the moodle system. You will be added to the corresponding MS-Team for the tutorials.

Exam

Written exam: to be announced

Note: This course will be presented in English, the final exam will be available in German too.

Re-exam

to be announced, presumably 1st week of the summer term

Information

This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

Requirements

  • basic knowledge of Organic Chemistry and Genetics
  • scope of the lectures:
    Bioinformatik I + II
    Computational Chemistry
    Softwarewerkzeuge der Bioinformatik or Structural Bioinformatics

The questionnaire gives you an idea about the required knowledge.
Due to technical limitations, the number of participants
will be limited to about 20.

Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master Program Bioinformatics)
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik
Structural Bioinformatics (Master Program Bioinformatics)

Content

The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

  • molecular origin of typical diseases and the mode of action of drugs
  • virtual substance libraries and query strategies
  • in silico eADMET models and filters, bioavailability
  • statistics and QSAR methods
  • metabolism, toxicology and adverse side effects, also considering biomarkers
  • polymorphism and susceptible genes
  • identification of orthologous genes to derive new targets and model organisms
  • current trends and strategies of drug design

Schein/Certification

Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam

Passing the two intermediate tests. These will be available in the moodle system.
First test: to be announced
Second test: to be announced

Leistungspunkte/Credits

5 (2 V + 1 Ü)

Language

This course is taught in English language.

Lectures

Lectures/Tutorials Slides Exercises
Lecture 1, October 25 Lecture 1 Assignment 1
Lecture 2, November 8  Lecture 2 Assignment 2
Tutorial 1, tba Tutorial 1
Lecture 3, November 15  Lecture 3
Lecture 4, November 22  Lecture 4 Assignment 3
Tutorial 2, tba Tutorial 2
Lecture 5, November 29 Lecture 5
Lecture 6, December 6  Lecture 6 Assignment 4
Tutorial 3, tba Tutorial 3
1st Test, tba
Lecture 7, December 13 Lecture 7
Lecture 8, January 3 Lecture 8 Assignment 5
Tutorial 4, tba Tutorial 4
Lecture 9, January 10 Lecture 9
Lecture 10, January 17 Lecture 10
2nd Test, tba
Lecture 11, January 24 Lecture 11
Lecture 12, January 31
Lecture (Feb 7) or exam