Special-topic Lecture Bioinformatics: Processing of Biological Data


Prof. Dr. Volkhard Helms


Rahmad Akbar, Daria Gaidar, Maryam Nazarieh, Duy Nguyen, Kerstin Neininger, Thorsten Will


Tuesday, 10:15 am – 11:45 am, building E2 1, room 007

Please regard the alternative dates and places of lectures in the schedule below!

First lecture: Friday, April 21st, 1:00 pm


Tuesday, 12:45 am – 02:00 pm, building E2 1, room 007.


This course can be used as a “Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics”


Intermediate programming skills in Python


    • clustering of data
    • principal component analysis
    • differential expression analysis
    • removal and correction of data outliers; prediction of missing values; BEclear method
    • processing of proteomics data; imputation of missing values
    • peak assignment
    • protein structure data (Protein DataBank); thermal mobility; titration states; hydration sites; PDBcheck
    • molecular dynamics simulations; time correlation of snapshots
    • analysis of multi-dimensional data

Conditions for certification:

Students need to pass the final exam.

There will be about six bi-weekly graded assignments and tutorial sessions. Students need to get at least 50% of the points from the assignments to be admitted to the final exam.


Students need to pass the written final exam that will be scheduled near the end of the summer semester or the re-exam that will be scheduled at the beginning of the following winter semester.


5 (2 V + 1 Ü)


This course is taught in English language.


Lecture 1, April 21 (Friday, 1:00 pm – 3:00 pm) ppt pdf
Lecture 2, April 26 (Wednesday, 8:30 am – 10:00 am) ppt pdf
Lecture 3, May 2 ppt pdf Assign1 Supplement
Lecture 4, May 9 ppt pdf
Lecture 5, May 19 (Friday, 2:15 pm – 4:00 pm, E2 1, room 106) ppt pdf  Assign2  Supplement
Lecture 6, May 23 ppt pdf
Lecture 7, May 30 ppt pdf Assign3 Supplement
Lecture 8, June 6 ppt pdf
Lecture 9, June 13 ppt pdf  Assign4  Supplement
Lecture 10, June 20 ppt pdf
Lecture 11, June 27 ppt pdf Assign5  Supplement
Lecture 12, July 4 ppt pdf
July 11 no lecture
July 18, 11 am – 1 pm Exam