Lecturer:
Tutor
Nicolas Künzel, Email: nicolas.kuenzel[at]bioinformatik.uni-saarland.de
Maximum number of participants:
12
Lecture:
block seminar: Wednesday – Friday, October 10th – 12th, 1:00 pm – 6:00 pm, E2 1. room 007
Preliminary meeting and placement of the topics:
Wednesday, July 18th, 2018, 3:00 pm, E2 1, room 007
Requirements:
Knowledge corresponding to semester 4 (proseminar) or knowledge corresponding to BSc degree (seminar)
Conditions for certification:
Successful presentation, regular participation (at least 60% of talks)
Leistungspunkte/Credits:
5 (proseminar) or 7 (seminar)
Additional Information:
Please regard the important hints for your seminar presentation!
Timetable for the talks:
| Wednesday, Oct. 10 | Thursday, Oct. 11 | Friday, Oct. 12 |
|---|---|---|
| 1 | 5 | 10 |
| 2 | 6 | 11 |
| 3 | 7 | 12 |
| 4 | 9 |
Topics:
- Statistics of protein-protein contacts
- Integrative structure determination of protein-protein complexes
- Protein-protein docking: algorithms + scoring methods + results (ClusPro)
- Co-evolutionary restraints + application in protein-protein docking (Gremlin) Only as seminar topic
- Binding free energy models for protein-protein complexes (Vangone & Bonvin) Only as proseminar topic
- Predicting hot spot residues at protein interfaces + machine learning
- Principles of Molecular dynamics simulations + MD simulations of protein-protein complexes Paper 1 Paper 2
- Principles of Brownian dynamics simulations + BD simulations of protein protein encounter
- Markov state models for protein ligand association Only as seminar topic
- Mutation-induced changes of PP binding affinity
- Effects of alternative splicing on protein complexes
- Phosphorylation-mediated protein interaction switches