Modern Methods in Drug Discovery WS 16/17

Tutor:

Dr. Michael Hutter

Lecture:

Monday, 10:15 am - 11:45 am, building E2 1, room 007, starting on October 31

Tutorial:

every second week, Thursdays, 04:15 pm - 05:45 pm, Dates: see below, Building E2 1, CIP Pool 003

Exam:

Please find the results of the exam of February 6th here.

Note: This course will be presented in English, the final exam will be available in German too.

Re-exam:

April 19th, 4:00 pm - 6:00 pm, E2 1, room 007

Information:

This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

Requirements:

  • basic knowledge of Organic Chemistry and Genetics
  • scope of the lectures:
    Bioinformatik I + II
    Computational Chemistry
    Softwarewerkzeuge der Bioinformatik

The questionnaire gives you an idea about the required knowledge.
Due to the limited capacity of the room, the number of participants
will be limited to about 20.

Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master program Bioinformatics)
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik

Content:

The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

  • molecular origin of typical diseases and the mode of action of drugs
  • virtual substance libraries and query strategies
  • in silico eADMET models and filters, bioavailability
  • statistics and QSAR methods
  • metabolism, toxicology and adverse side effects, also considering biomarkers
  • polymorphism and susceptible genes
  • identification of orthologous genes to derive new targets and model organisms
  • current trends and strategies of drug design

Schein/Certification:

Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam:

At least 50% of the points of the assignments.

Leistungspunkte/Credits:

5 (2 V + 1 Ü)

Language

This course is taught in English language.

Lectures:

LecturesSlidesExcercises
Lecture 1, October 31pdfpdf
Lecture 2, November 7pdf
Lecture 3, November 14pdfpdf
Tutorial 1, November 10 (CIP-room)pdf
Lecture 4, November 21pdf
Lecture 5, November 28pdf
NO LECTURE TODAY
pdf
Tutorial 2, November 24 (CIP-room)pdf
Lecture 6, December 5pdfpdf
Lecture 7, December 12pdf
Tutorial 3, December 8 (CIP-room)pdf
Lecture 8, January 2pdfpdf
Lecture 9, January 9pdf
Tutorial 4, January 12 (CIP-room)pdf
Lecture 10, January 16pdfpdf
Lecture 11, January 23pdf
Tutorial 5, January 26 (CIP-room)roundup
Lecture 12, January 30pdf
Exam, February 6
February 13Exam evaluation/
Klausureinsicht