Lecturer:
Tutor:
PD Dr. Michael Hutter
Lecture:
Monday, 10:15 am – 11:45 am, building E2 1, room 007, starting on October 23, 2017
Tutorial:
every second week, Thursdays, 04:15 pm – 05:45 pm, Dates: see table below, building E2 1, CIP pool 003
Exam:
Note: This course will be presented in English, the final exam will be available in German too.
Re-exam:
Information:
This course can be used as a “Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics”
Requirements:
- basic knowledge of Organic Chemistry and Genetics
- scope of the lectures:
Bioinformatik I + II
Computational Chemistry
Softwarewerkzeuge der Bioinformatik
The questionnaire gives you an idea about the required knowledge.
Due to the limited capacity of the room, the number of participants
will be limited to about 20.
Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master program Bioinformatics)
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik
Content:
The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:
- molecular origin of typical diseases and the mode of action of drugs
- virtual substance libraries and query strategies
- in silico eADMET models and filters, bioavailability
- statistics and QSAR methods
- metabolism, toxicology and adverse side effects, also considering biomarkers
- polymorphism and susceptible genes
- identification of orthologous genes to derive new targets and model organisms
- current trends and strategies of drug design
Schein/Certification:
Grade of certification (“Schein”) is based on the final exam only.
Condition for participation in the final exam:
At least 50% of the points of the assignments.
Leistungspunkte/Credits:
5 (2 V + 1 Ü)
Language
This course is taught in English language.
Lectures:
| Lectures/Tutorials | Slides | Exercises |
| Lecture 1, October 23 | Lecture 1 | Assignment 1 |
| Lecture 2, October 30 | Lecture 2 | |
| Lecture 3, November 6 | Lecture 3 | Assignment 2 |
| Tutorial 1, November 9 | Tutorial 1 | |
| Lecture 4, November 13 | Lecture 4 | |
| Lecture 5, November 20 | Lecture 5 | Assignment 3 |
| Tutorial 2, November 23 | Tutorial 2 | |
| Lecture 6, November 27 | Lecture 6 | |
| Lecture 7, December 4 | Lecture 7 | Assignment 4 |
| Tutorial 3, December 7 | Tutorial 3 | |
| Lecture 8, December 11 | Lecture 8 |
Assignment 5 |
| Tutorial 4, December 14 | Tutorial 4 | |
| Lecture 9, December 18 | Lecture 9 | |
| Lecture 10, January 8 | Lecture 10 | |
| Lecture 11, January 15 | Lecture 11 | |
| Tutorial 5, January 18 | ||
| Exam, January 22 | ||
| Exam evaluation, January 29 |