Lecturer: Prof. Dr. Volkhard Helms
Tutor: Mohamed Hamed, Ruslan Akulenko, Christian Spaniol
Lecture: Tuesday, 10:15 am – 11:45 am, building E2 1, room 007
Tutorial: Tuesday, 12:45 am – 02:00 pm, building E2 1, room 007, starting on April 30
Information: This course can be used as a “Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics”
Leistungspunkte/Credits:
5 (2 V + 1 Ü)
This course is taught in English language.
Conditions for certification: There will be three 45-minutes tests on different parts of the lecture. (a) Students need to pass at least two out of the three tests. (b) Students need to get at least 50% of the points from the assignments.
Schein/Certification: An averaged score will be computed from the best two results of the three tests and this yields the grade of certification (“Schein”). There will be no final exam.
There will be about six bi-weekly assignments and tutorial sessions.
Content:
(a) biological content
- cell cycle
- cell differentiation/cell reprogramming
- development of cancer
(b) bioinformatics content
- microarray expression analysis
- DNA methylation analysis
- GO and pathway annotation
- interaction networks
- application of clustering techniques
- construction of gene-regulatory networks
- stochastic simulations
(c) mathematics content
- stochastic processes + noise
- differential equations
- non-linear systems, bifurcations
Requirements:
no formal requirements, but solid prior knowledge about
- cellular networks
- genetics
- omics technologies
- programming experience
Lectures:
| Lecture 1, April 16 | ppt | ||
| Lecture 2, April 23 | ppt | ||
| Lecture 3, April 30 | ppt | Assignment 1 | |
| Lecture 4, May 7 | ppt | ||
| Lecture 5, May 14 | Test 1 ppt | Assignment 2 | |
| Lecture 6, May 21 | ppt | ||
| Lecture 7, May 28 | ppt | Assignment 3 data |
|
| June 4 | no lecture | ||
| Lecture 8, June 11 | ppt | ||
| Lecture 9, June 18 | Test 2 ppt | Assignment 4 data |
|
| Lecture 10, June 25 | ppt | ||
| Lecture 11, July 2 | Assignment 5 data1 data2 |
||
| July 9 | no lecture | ||
| Lecture 12, July 16 | ppt | ||
| July 23 | Test 3 | Assignment 6 data |